Amyotrophic lateral sclerosis
 Discussion of Amyotrophic lateral sclerosis
- Amyotrophic lateral sclerosis is aka Lou Gehrig's disease.
- Amyotrophic lateral sclerosis is a devastating, progressive, neurodegenerative disorder that demonstrates both upper (hyperreflexia, spasticity) and lower (fasciculation, atrophy) neuronal symptoms.
- Amyotrophic lateral sclerosis demonstrates a male predilection with onset in the middle and late adult years.
- The exact cause of the disease is not well known.
- The primary role of imaging in amyotrophic lateral sclerosis is to exclude other causes such as cervical degenerative disk disease or multiple sclerosis.
 Imaging Findings for Amyotrophic lateral sclerosis
- Fairly typical MR imaging findings have been described in patients with amyotrophic lateral sclerosis.
- High signal intensity is seen involving the corticospinal tract at T2-weighted imaging.
- This abnormal signal intensity extends from the corona radiata, through the most caudal aspect of the posterior limb of the internal capsule, into the ventral aspect of the brain stem, and finally into the anterolateral column of the spinal cord.
- In addition, T2-weighted MR imaging typically demonstrates low signal intensity in the motor cortex in amyotrophic lateral sclerosis. This finding has been attributed to T2 shortening due to iron deposition.
 See also
 External Links
 References for Amyotrophic lateral sclerosis
- Salah M. Khader, and Francis G. Greiner. Neuroradiology Case of the Day. RadioGraphics 1999 19: 1696-1698.