Amyotrophic lateral sclerosis

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[edit] Discussion of Amyotrophic lateral sclerosis

Lou Gehrig
  • Amyotrophic lateral sclerosis is aka Lou Gehrig's disease.
  • Amyotrophic lateral sclerosis is a devastating, progressive, neurodegenerative disorder that demonstrates both upper (hyperreflexia, spasticity) and lower (fasciculation, atrophy) neuronal symptoms.
  • Amyotrophic lateral sclerosis demonstrates a male predilection with onset in the middle and late adult years.
  • The exact cause of the disease is not well known.



[edit] Imaging Findings for Amyotrophic lateral sclerosis

  • Fairly typical MR imaging findings have been described in patients with amyotrophic lateral sclerosis.
  • High signal intensity is seen involving the corticospinal tract at T2-weighted imaging.
  • This abnormal signal intensity extends from the corona radiata, through the most caudal aspect of the posterior limb of the internal capsule, into the ventral aspect of the brain stem, and finally into the anterolateral column of the spinal cord.
  • In addition, T2-weighted MR imaging typically demonstrates low signal intensity in the motor cortex in amyotrophic lateral sclerosis. This finding has been attributed to T2 shortening due to iron deposition.

[edit] Images

Patient #1

[edit] See also

[edit] External Links

Goldminer: Amyotrophic lateral sclerosis

[edit] References for Amyotrophic lateral sclerosis