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 Discussion of Cardiac amyloidosis
- Amyloidosis represents the extra-cellular deposition of insoluble fibrillar proteinaceous material in various organs and tissues in a variety of clinical settings.
- Cardiac involvement is seen with most forms of amyloidosis, although it is most common and most often clinically significant with primary amyloidosis (i.e associated with multiple myeloma or other monoclonal gammopathies).
- Amyloidosis is the most common cause of restrictive cardiomyopathy outside the tropics.
- Differentiation of amyloidosis from other forms of restrictive cardiomyopathy (i.e hypertrophic cardiomyopathy, cardiac sarcoidosis, or infiltrative lymphoma) is important for appropriate treatment.
 Imaging Findings for Cardiac amyloidosis
- Diffuse heterogeneous pattern of increased signal on delayed contrast enhanced inversion recovery T1-weighted images (this is an aunt minnie).
- Other typical features of restrictive cardiomyopathy:
- Left ventricular wall thickening
- Reduced systolic function with decreased ejection fraction
- Restriction of diastolic filling
- Disproportionate atrial enlargement
 See Also
 External Links
 References for Cardiac amyloidosis
- vanden Driesen, Rohan I., Slaughter, Richard E., Strugnell, Wendy E. MR Findings in Cardiac Amyloidosis. Am. J. Roentgenol. 2006 186: 1682-1685.