- Adenocarcinoma that arises from the bile duct epithelium.
- Second most prevalent liver cancer after hepatocellular carcinoma.
- Usually classified as either intrahepatic or extrahepatic
- Intrahepatic cholangiocarcinoma is further classified as either peripheral or hilar.
- Tumor that arises from one of the hepatic ducts or the bifurcation of the common hepatic duct is considered to be hilar cholangiocarcinoma (Klatskin tumor).
- M&M: most patients die within a year of diagnosis.
 Imaging Findings
- Delayed enhancement
- Delayed enhancement with increasing attenuation may be seen on images in as many as 74% of patients.
- This pattern of enhancement may be useful in differentiating HCC from cholangiocarcinomas. HCC shows an early peak increase in attenuation with a progressive decrease.
- The overlying liver capsule may be retracted when the lesions are peripheral.
Patient #1: Delayed enhanced CT images demonstrate cholangiocarcinoma in the right hepatic lobe.
 See Also
 External Links
- E-medicine rads article by Mahesh Kumar Neelala Anand, MBBS, DNB, FRCR.
- Joon Koo Han, Byung Ihn Choi, Ah Young Kim, Su Kyung An, Joon Woo Lee, Tae Kyung Kim, and Sun-Whe Kim. Cholangiocarcinoma: Pictorial Essay of CT and Cholangiographic Findings. RadioGraphics 2002 22: 173-187.