Cryptogenic organizing pneumonia

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[edit] Discussion

  • COP is an idiopathic intersitial pneumonias with characteristic clinical and radiologic features.
  • The histologic pattern of COP is organizing pneumonia, formerly referred to as bronchiolitis obliterans organizing pneumonia (BOOP).
  • The term BOOP has been omitted to avoid confusion with airway diseases such as constrictive bronchiolitis.


Clinical Features

  • Mean age of 55 years.
  • Present with mild dyspnea, cough, and fever that have been developing over a few weeks.
  • Patients typically report a respiratory tract infection preceding their symptoms.
  • There is no association with cigarette smoking
  • The majority of patients recover completely after administration of corticosteroids, but relapses occur frequently within 3 months after corticosteroid therapy.


[edit] Imaging Findings

[edit] Plain film

  • The chest radiograph in patients with COP usually shows unilateral or bilateral patchy consolidations that resemble pneumonic infiltrates.
  • However, the consolidations in COP do not represent an active pneumonia but result from intraalveolar fibroblast proliferations.
  • Some patients present with nodular opacities on the chest radiograph.

[edit] CT

  • Frequently, the CT findings are far more extensive than expected from a review of the plain chest radiograph.
  • Characteristic peripheral or peribronchial distribution, and the lower lung lobes are more frequently involved.
  • In some cases, the outermost subpleural area is spared.
  • Typically, the appearance of the lung opacities varies from ground glass to consolidation.
    • These opacities have a tendency to migrate, changing location and size, even without treatment.
    • They are of variable size, ranging from a few centimeters to an entire lobe.
    • Reversed halo sign

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] References