Cystitis cystica and glandularis

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[edit] Discussion of Cystitis cystica and glandularis

  • Cystitis cystica and cystitis glandularis are common chronic reactive inflammatory disorders that occur in the setting of chronic irritation.
  • Metaplasia of the urothelium is incited by irritants such as infection, calculi, outlet obstruction, or tumor.
  • The urothelium then proliferates into buds, which grow down into the connective tissue beneath the epithelium in the lamina propria.
  • The buds then differentiate into cystic deposits of cystitis cystica or into goblet cells resulting in cystitis glandularis.
  • The histologic features of both cystitis cystica and cystitis glandularis are usually present, rather than either in its pure form.


  • Cystitis glandularis can occur in association with pelvic lipomatosis and is believed to result from bladder obstruction and chronic infection.
  • Bladder exstrophy is also associated with diffuse cystitis glandularis.
  • Biopsy is necessary for a definitive diagnosis.
  • Treatment consists of removing the source of irritation and surgical excision of the area of inflammation or cystectomy in rare severe cases.
  • These patients should be monitored carefully because of the possible association with adenocarcinoma.


[edit] Imaging Findings for Cystitis cystica and glandularis

  • Masses from cystitis cystica and cystitis glandularis vary in number and size and manifest as filling defects at urography.
  • A hypervascular polypoid mass has been observed on CT and MR images, with low signal intensity reported with T1-weighted sequences. On T2-weighted images, the lesion was predominantly low in signal intensity with a central branching high-signal-intensity pattern.

[edit] Images

Patient #1

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[edit] References for Cystitis cystica and glandularis