Eye of the tiger sign

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[edit] Discussion of Eye of the tiger sign

  • The eye-of-the-tiger sign is most commonly referenced in association with Hallervorden-Spatz syndrome.
  • The sign has been reported in other extrapyramidal parkinsonian disorders, including cortical–basal ganglionic degeneration, early-onset levodopa-responsive parkinsonism, and Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy).


[edit] Imaging Findings for Eye of the tiger sign

  • On T2-weighted magnetic resonance images, marked low signal intensity circumscribes the globus pallidus, producing an eye-of-the-tiger appearance
    • Ring of marked hypointensity involving the globus pallidus on T2-weighted MR images is due to excess iron accumulation.
    • The central high signal intensity of the globus pallidus has been attributed to gliosis, increased water content, and neuronal loss with disintegration, vacuolization, and cavitation of the neuropil.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] Misc

Eye of the Tiger Clip from Rocky III



[edit] References for Eye of the tiger sign