Eye of the tiger sign
 Discussion of Eye of the tiger sign
- The eye-of-the-tiger sign is most commonly referenced in association with Hallervorden-Spatz syndrome.
- The sign has been reported in other extrapyramidal parkinsonian disorders, including cortical–basal ganglionic degeneration, early-onset levodopa-responsive parkinsonism, and Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy).
 Imaging Findings for Eye of the tiger sign
- On T2-weighted magnetic resonance images, marked low signal intensity circumscribes the globus pallidus, producing an eye-of-the-tiger appearance
- Ring of marked hypointensity involving the globus pallidus on T2-weighted MR images is due to excess iron accumulation.
- The central high signal intensity of the globus pallidus has been attributed to gliosis, increased water content, and neuronal loss with disintegration, vacuolization, and cavitation of the neuropil.
 See Also
 External Links
Eye of the Tiger Clip from Rocky III
 References for Eye of the tiger sign
- R. Paul Guillerman. The Eye-of-the-Tiger Sign. Radiology 2000 217: 895-896.