Fibrosarcoma

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[edit] Discussion

  • Tumor of mesenchymal cell origin that is composed of malignant fibroblasts in a collagen background.
  • It can occur as a soft-tissue mass or as a primary or secondary bone tumor.
  • Fibrosarcoma was diagnosed much more frequently in the past; it is now more reliably distinguished histologically from similar lesions, such as desmoid tumors, malignant fibrous histiocytoma, malignant schwannoma, and high-grade osteosarcoma.


  • Fibrosarcoma represents only about 10% of musculoskeletal sarcomas
  • Fibrosarcoma of bone can be diagnosed in patients of any age, but it is diagnosed more commonly in patients in the fourth decade of life.
  • It is usually located in the lower extremities, especially the femur and tibia.


  • Fibrosarcoma of the soft tissues usually affects a wider age spectrum of patients than fibrosarcoma of the bone does, with an age range of 35-55 years.
  • It often arises in the soft tissues of the thigh and the posterior knee.
  • It is generally a large, painless mass deep to fascia and has an ill-defined margin.


  • An infantile form (in children <10 y) of fibrosarcoma exists. Unlike fibrosarcoma in adults, it has an excellent prognosis—even in the face of metastatic disease at presentation—when treated with a combination of neoadjuvant and adjuvant chemotherapy and resection.

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Patient #1

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