Gallium-67 citrate

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Contents

[edit] Photon energy

93, 185, 300, 394 keV

[edit] Uses, dosages, and Time of imaging

  • Infection/inflammation
    • Dose:
      • Adult: 5 mCi IV
      • Peds: 40 uCi/kg IV
    • Time of imaging: 48 hours (may image at 6-24 hours to minimize bowel activity)
  • Tumor
    • Dose:
      • Adult: 10 mCi IV
      • Peds: 40 uCi/kg IV
    • Time of imaging: 48 hours (may image at 6-24 hours to minimize bowel activity)

[edit] Physical half life

78 hours

[edit] Biological half life

25 days

[edit] Normal distribution

  • Liver, spleen, bone marrow, salivary and lacrimal glands, kidneys (24 hrs)
  • Lungs (24 hrs)

[edit] Pharmacokinetics

  • Acts like ferric ion analog; circulates in blood bound to transferin; transported to cellular receptors and incorporated intracellularly;
  • Delivery to inflamed site due to increased blood flow and vascular permeability; neutrophil degradation deposits lactoferrin to which Ga-67 binds

[edit] Excretion

Renal, colon

[edit] Target organ

Colon

[edit] Other