Giant cell tumor
 Discussion of Giant cell tumor
- Giant cell tumor (GCT) is a relatively common skeletal tumor, accounting for 4%–9.5% of all primary osseous neoplasms and 18%–23% of benign bone neoplasms.
- Radiography often strongly suggests the diagnosis and reveals an eccentric, lytic lesion centered in the metaepiphysis and extending to subchondral bone with expansile remodeling but lacking internal mineralization.
- GCT is typically benign but 5%–10% of lesions may be malignant.
- At histologic analysis, GCTs contain a prominent and diffuse osteoclastic giant cell component and have been referred to in the past as osteoclastomas.
- GCT may be associated with secondary aneurysmal bone cyst formation (14% of lesions).
- Paget disease is rarely associated with either solitary or multiple GCT
- The peak prevalence is in the third decade of life.
- The location of GCT is one of the most important features suggesting the diagnosis because approximately 84%–99% of lesions extend to within 1 cm of subarticular bone.
- The most common specific location of GCT is about the knee (50%–65% of cases)
 Imaging Findings for Giant cell tumor
 Plain film
- Eccentric, lytic lesion centered in the metaepiphysis and extending to subchondral bone with expansile remodeling but lacking internal mineralization
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 References for Giant cell tumor
- Mark D. Murphey, George C. Nomikos, Donald J. Flemming, Francis H. Gannon, H. Thomas Temple, and Mark J. Kransdorf. Imaging of Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone: Radiologic-Pathologic Correlation. RadioGraphics 2001 21: 1283-1309.