Discussion of Gorham syndrome
- Gorham syndrome is also known as Gorham-Stout syndrome, massive osteolysis, idiopathic osteolysis, disappearing bone disease, phantom bone disease, vanishing bone disease, spontaneous absorption of bone, progressive atrophy of bone, or hemangiomatosis or lymphangiomatosis of bone.
- Gorham syndrome is a rare disorder with approx 200 reported cases.
- This disease may occur at any age; however, it is most often recognized in children and young adults.
- There is no sex predilection or inheritance pattern.
- 57% of patients have a history of trauma.
- Massive and progressive osteolysis is caused by the proliferation of abnormal thin-walled endothelial-lined capillaries of vascular or lymphatic origin.
- The mechanism of bone resorption is unknown.
- The skeletal distribution of the disease has been widespread, but the upper arm or shoulder girdle (26%) and mandible (15%) have been favored sites.
- Skeletal involvement is virtually always monocentric, and involvement of adjacent bones occurs by means of direct spread.
- The differential diagnosis of Gorham syndrome includes skeletal angioma, angiosarcoma, essential osteolysis, and hereditary osteolysis.
 Imaging Findings for Gorham syndrome
- Radiographically, the earliest changes are foci of intramedullary and subcortical lucency resembling osteoporosis.
- Concentric reduction results in tapering of involved long bones.
- This is followed by complete resorption of the involved bone in severe cases.
- A typical and notable finding is the lack of sclerosis or osteoblastic reaction.
 See Also
 External Links
 References for Gorham syndrome
- Jannette Collins. Case 92: Gorham Syndrome. Radiology 2006 238: 1066-1069.