I-131 MIBG

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Contents

[edit] Full name

I-131 meta-iodo-benzyl-guanidine

[edit] Photon energy

364 keV

[edit] Uses, dosages, and Time of imaging

  • Tumor
    • Dose: 0.5 mCi/m2 IV over 15-30 seconds
    • Time of imaging: 24, 48, 72 hours

[edit] Physical half life

8.1 days

[edit] Biological half life

[edit] Normal distribution

Liver, spleen, salivary glands, thyroid

[edit] Pharmacokinetics

  • Structure similar to norepinephrine and guanethidine
  • Localizes through NE reuptake mechanizm in catecholamine storage vesicles in presynaptic adrenergic nerve endings and cells of adrenal medulla

[edit] Excretion

[edit] Target organ

[edit] Other

  • Tumors: pheochromocytoma, paraganglioma, neuroblastoma, carcinoid, medullary thyroid carcinoma
  • Block thyroid with SSKI or Lugol's solution
  • Interfering drugs: tricyclic antidepressants, reserpine, guanethidine, certain antipsychotics, cocaine, labetolol

[edit] Images

Normal MIBG Scan