Leydig cell hyperplasia

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[edit] Discussion of Leydig cell hyperplasia

  • Leydig cell hyperplasia is a rare, benign condition characterized by multiple small testicular nodules, frequently bilateral.
  • Various conditions have been associated with Leydig cell hyperplasia, including cryptorchidism, congenital adrenal hyperplasia, human chorionic gonadotropin (hCG)–producing germ cell tumors, Klinefelter syndrome, and exogenous hCG therapy.


  • When bilateral multifocal testicular masses are identified, the possibility of benign Leydig cell hyperplasia should be considered, as this gives the urologist the option of performing a surgical biopsy rather than orchiectomy to exclude malignancy.
  • The differential diagnosis for multiple nodular lesions includes lymphoma, leukemia, metastatic disease, granulomatous disease, and bilateral primary testicular neoplasm.

[edit] Imaging Findings for Leydig cell hyperplasia

  • The sonographic appearance can be variable, with both hypoechoic and hyperechoic appearances having been described.
  • At MR imaging, multiple small (1–6-mm) nodules are seen, which are hypointense on T2-weighted images. There may be mild enhancement after administration of gadolinium.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] References for Leydig cell hyperplasia