Lymphocytic adenohypophysitis

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[edit] Discussion of Lymphocytic adenohypophysitis

  • Lymphocytic adenohypophysitis is a rare autoimmune inflammatory disorder of the anterior lobe of the pituitary gland
  • May affect young women in the peripartum.
  • Female-to-male ratio of approximately 10:1.
  • Associated with other autoimmune diseases such as autoimmune thyroiditis and pernicious anemia.


  • Lymphocytic adenohypophysitis results most often in early failure of adrenocorticotropic hormone and thyroid-stimulating hormone
  • Postpartum hypoprolactinemia (level < 150 ng/mL) is seen in the majority of patients with lymphocytic adenohypophysitis. This is attributed to pituitary parenchymal damage caused by the severe inflammatory reaction.


  • Steroids have been advocated as the main line of treatment. Glucocorticoids replace the shortage of a vital hormone and have a potent anti-inflammatory effect.

[edit] Imaging Findings for Lymphocytic adenohypophysitis

[edit] MRI

  • There are no imaging features that distinguish lymphocytic adenohypophysitis from a pituitary adenoma
  • Enlargement of the pituitary gland with suprasellar extension in 60%–80% of patients.
  • In the majority of patients, there is early and homogeneous enhancement of the pituitary gland.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] References for Lymphocytic adenohypophysitis