Discussion of Lymphocytic adenohypophysitis
- Lymphocytic adenohypophysitis is a rare autoimmune inflammatory disorder of the anterior lobe of the pituitary gland
- May affect young women in the peripartum.
- Female-to-male ratio of approximately 10:1.
- Associated with other autoimmune diseases such as autoimmune thyroiditis and pernicious anemia.
- Lymphocytic adenohypophysitis results most often in early failure of adrenocorticotropic hormone and thyroid-stimulating hormone
- Postpartum hypoprolactinemia (level < 150 ng/mL) is seen in the majority of patients with lymphocytic adenohypophysitis. This is attributed to pituitary parenchymal damage caused by the severe inflammatory reaction.
- Steroids have been advocated as the main line of treatment. Glucocorticoids replace the shortage of a vital hormone and have a potent anti-inflammatory effect.
 Imaging Findings for Lymphocytic adenohypophysitis
- There are no imaging features that distinguish lymphocytic adenohypophysitis from a pituitary adenoma
- Enlargement of the pituitary gland with suprasellar extension in 60%–80% of patients.
- In the majority of patients, there is early and homogeneous enhancement of the pituitary gland.
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 References for Lymphocytic adenohypophysitis
- Imad T. Zak, Harjot S. Dulai, and Karl K. Kish. Imaging of Neurologic Disorders Associated with Pregnancy and the Postpartum Period. RadioGraphics 2007 27: 95-108.