Male breast cancer

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[edit] Discussion of Male breast cancer

  • Male breast cancer accounts for 0.7% of total breast cancers.
  • Mean age of diagnosis is 67 years
  • Approximately 85% of primary male breast cancers are invasive ductal carcinoma of the "not otherwise specified" subtype.
  • Risk factors include:
    • Advanced age
    • Prior irradiation of the chest
    • Exogenous estrogen for prostate cancer treatment and gender-reassignment procedures
    • Liver disease and other diseases associated with hyperestrogenism
    • Androgen deficiency due to testicular dysfunction
    • Certain genetic and chromosomal conditions such as BRCA2 mutation and Klinefelter syndrome


  • Most common presentation in these patients is a palpable mass.
  • Palpable axillary lymph nodes are present in about 50% of cases.
  • Staging and treatment are similar to those of female breast cancer.

[edit] Imaging Findings for Male breast cancer

[edit] Mammogram

  • At mammography, these are typically high-density irregular masses with well-defined contours.
  • Margins are usually spiculated, lobulated, or microlobulated.
  • Most are retroareolar since male breast cancers commonly arise from central ducts.
  • They can be distinguished from benign gynecomastia by appearing as a discrete mass.
  • Eccentric location is not typical for benign gynecomastia and is suspicious for carcinoma.
  • Microcalcification is less commonly seen in males than in females.
  • Nipple retraction, skin thickening, and increased trabeculation are helpful secondary signs and carry a poor prognosis.


[edit] US

  • Male breast cancers have similar US features as in women.
  • Discrete, hypoechoic masses with margins that are angulated, microlobulated, or spiculated.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] References for Male breast cancer