Discussion of Marjolin's ulcer
- Marjolin's ulcer refers to long-term malignant complications in scars mainly resulting from burns.
- Several carcinogenic factors are thought to act together to trigger carcinogenesis.
- The average age at diagnosis is in the fifth decade of life.
- Men are three times more frequently affected than women.
- Average latency reported for malignant changes of burn scar carcinoma is approximately 35 years.
- Majority of reported cases are squamous cell carcinoma, but other types of malignancies such as basal cell carcinoma, malignant melanoma, liposarcoma, osteosarcoma, adenocarcinoma, and fibrosarcoma can also be seen.
- Most lesions of Marjolin's ulcer occur on the extremities (60%).
- Wide excision (surgical margin of at least 2 cm) together with skin grafting is usually considered appropriate in the treatment of Marjolin's ulcer
- Marjolin's ulcer tends to be more aggressive than other types of skin cancer and has a higher regional metastasis and fatality rate.
- The 5-year survival rate is only about 40-60%
 Imaging Findings for Marjolin's ulcer
- Radiography provides information about periosteal reaction.
- MRI shows the margins and extent of destruction well.
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 References for Marjolin's ulcer
- Chiang, Kuo-Hsien, Chou, Andy Shau-Bin, Hsu, Yung-Hsiang, Lee, Sea-Kiat, Lee, Chau-Chin, Yen, Pao-Sheng, Ling, Chang-Ming, Lee, Wei-Hsing, Lin, Chao-Chun, Chang, Pau-Yang. Marjolin's Ulcer: MR Appearance. Am. J. Roentgenol. 2006 186: 819-820.