Discussion of Melorheostosis
- Melorheostosis is usually discovered in childhood, occasionally in adulthood.
- The male-to-female ratio is usually 1:1.
- It can occur in a single limb, and the lower extremity is more commonly affected than the upper extremity.
- The epicenter is periosteal or endosteal. The appearance consists of cortical hyperostosis in one or multiple bones, often with intervening soft-tissue calcification or ossification.
- The limb involved with melorheostosis often demonstrates joint pain, swelling, and limitation of motion in childhood.
- There is often associated growth disturbance, muscular contraction, and limb length discrepancy.
- There may be overlying skin changes.
- At pathologic analysis, thickened and enlarged osseous trabeculae are noted, associated with fibrous tissue replacement of the marrow space.
- There is controversy involving the distribution of melorheostosis. It has been suggested that the distribution mimics that of the sclerotomes (zones supplied by individual spinal sensory nerves), implying a neurogenic origin.
 Imaging Findings for Melorheostosis
- At radiography, contiguous bones of an extremity are often involved, although there may be involvement of a single bone.
- There is cortical hyperostosis with intervening soft-tissue calcification or ossification. Dripping candle wax appearance.
- There may be endosteal hyperostosis with obliteration of the medullary space.
 See Also
 External Links
 References for Melorheostosis
- Scott M. Levine, Robert E. Lambiase, and Catherine N. Petchprapa. Cortical Lesions of the Tibia: Characteristic Appearances at Conventional Radiography. RadioGraphics 2003 23: 157-177.