Melorheostosis

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[edit] Discussion of Melorheostosis

Candle Wax
  • Melorheostosis is usually discovered in childhood, occasionally in adulthood.
  • The male-to-female ratio is usually 1:1.
  • It can occur in a single limb, and the lower extremity is more commonly affected than the upper extremity.
  • The epicenter is periosteal or endosteal. The appearance consists of cortical hyperostosis in one or multiple bones, often with intervening soft-tissue calcification or ossification.
  • The limb involved with melorheostosis often demonstrates joint pain, swelling, and limitation of motion in childhood.
  • There is often associated growth disturbance, muscular contraction, and limb length discrepancy.
  • There may be overlying skin changes.
  • At pathologic analysis, thickened and enlarged osseous trabeculae are noted, associated with fibrous tissue replacement of the marrow space.
  • There is controversy involving the distribution of melorheostosis. It has been suggested that the distribution mimics that of the sclerotomes (zones supplied by individual spinal sensory nerves), implying a neurogenic origin.

[edit] Imaging Findings for Melorheostosis

  • At radiography, contiguous bones of an extremity are often involved, although there may be involvement of a single bone.
  • There is cortical hyperostosis with intervening soft-tissue calcification or ossification. Dripping candle wax appearance.
  • There may be endosteal hyperostosis with obliteration of the medullary space.

[edit] Images

Patient #1

[edit] See Also

[edit] External Links

[edit] References for Melorheostosis