Discussion of Multiple sclerosis
- Multiple sclerosis (MS) is an inflammatory demyelinating condition of unclear etiology.
- White matter tracts are affected, including those of the cerebral hemispheres, infratentorium, and spinal cord.
- MS plaques may form in CNS white matter in any location; thus, clinical presentations may be diverse.
- Continuing lesion formation in MS often leads to physical disability and, sometimes, to cognitive decline.
- MS is most prevalent in white persons of northern European descent and in persons living in temperate climates (suggests that both genetic and environmental factors influence the frequency of MS)
- Male-to-female ratio is approximately 1:2.
- MS is a disease of early adulthood.
- MS is diagnosed with the demonstration of white matter dysfunction disseminated in time and space.
- The clinical course of MS can follow different patterns. Relapsing-remitting MS is the most commom.
 Imaging Findings for Multiple sclerosis
- MS plaques display T2 hyperintensity
- Lesions may be observed anywhere in the CNS white matter
- Typical locations include the periventricular white matter, brainstem, cerebellum, and spinal cord.
- Ovoid lesions perpendicular to the ventricles are common in MS and occasionally are called Dawson fingers, which occur along the path of the deep medullary veins.
- Most specific lesions for MS are noted in the corpus callosum at the interface with the septum pellucidum.
- Gadolinium-enhanced T1-weighted MRIs can depict acute active MS lesions. These appear as enhancing white matter lesions.
 Multiple sclerosis Variants
Balo's (concentric sclerosis)
- Alternating bands of myelination and demyelination, often in concentric fashion
- Rapid course with death in several months.
- Severe axonal loss
Devic disease (Neuromyelitis optica)
Patient #2: Contrast enchancement of several lesions indicates active disease
 See Also
 External Links
 References for Multiple sclerosis
- E-medicine radiology article on multiple sclerosis