Multiple sclerosis

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[edit] Discussion of Multiple sclerosis

  • Multiple sclerosis (MS) is an inflammatory demyelinating condition of unclear etiology.
  • White matter tracts are affected, including those of the cerebral hemispheres, infratentorium, and spinal cord.
  • MS plaques may form in CNS white matter in any location; thus, clinical presentations may be diverse.
  • Continuing lesion formation in MS often leads to physical disability and, sometimes, to cognitive decline.


  • MS is most prevalent in white persons of northern European descent and in persons living in temperate climates (suggests that both genetic and environmental factors influence the frequency of MS)
  • Male-to-female ratio is approximately 1:2.
  • MS is a disease of early adulthood.
  • MS is diagnosed with the demonstration of white matter dysfunction disseminated in time and space.
  • The clinical course of MS can follow different patterns. Relapsing-remitting MS is the most commom.

[edit] Imaging Findings for Multiple sclerosis

[edit] MRI

  • MS plaques display T2 hyperintensity
  • Lesions may be observed anywhere in the CNS white matter
  • Typical locations include the periventricular white matter, brainstem, cerebellum, and spinal cord.
  • Ovoid lesions perpendicular to the ventricles are common in MS and occasionally are called Dawson fingers, which occur along the path of the deep medullary veins.
  • Most specific lesions for MS are noted in the corpus callosum at the interface with the septum pellucidum.


  • Gadolinium-enhanced T1-weighted MRIs can depict acute active MS lesions. These appear as enhancing white matter lesions.


[edit] Multiple sclerosis Variants

Balo's (concentric sclerosis)

  • Alternating bands of myelination and demyelination, often in concentric fashion

Marburg (acute)

  • Rapid course with death in several months.
  • Severe axonal loss

Devic disease (Neuromyelitis optica)

[edit] Images

Patient #1

Patient #2: Contrast enchancement of several lesions indicates active disease

[edit] See Also

[edit] External Links

[edit] Misc

Image:S&m-walk.gif

http://www.mordantorange.com

[edit] References for Multiple sclerosis