Discussion of Osteopetrosis
- AKA Albers-Schonberg disease
- Heterogeneous group of osteosclerotic bone dysplasias
- The entire skeleton is unusually dense.
- Impaired bone resorption results in abundant osteoid and narrow, fibrotic medullary spaces.
- Hematologic derangements are due to the diminished hematopoietic compartment.
- Bones are fragile and prone to fracture and show a high susceptibility to osteomyelitis.
- Neural and vascular foramina are narrow, causing cranial nerve palsies by neural compression.
- Two modes of inheritance are known.
- Dominant osteopetrosis, which has a benign course and late manifestation
- Autsomal recessive:
- Malignant form manifests at birth
- Intermediate autosomal recessive form manifests in the first decade of life.
 Imaging Findings for Osteopetrosis
Patient #1: Plain films and MRI images from a patient with osteopetrosis
 See also
 External Links
 References for Osteopetrosis
- Ronald B. J. Glass, Sandra K. Fernbach, Karen I. Norton, Paul S. Choi, and Thomas P. Naidich. The Infant Skull: A Vault of Information. RadioGraphics 2004 24: 507-522.