Paroxysmal nocturnal hemoglobinuria
 Discussion of Paroxysmal nocturnal hemoglobinuria
- Paroxysmal nocturnal hemoglobinuria is an acquired disorder of hematopoietic stem cells that results in an abnormal predisposition to complement-mediated hemolysis.
- Clinically, paroxysmal nocturnal hemoglobinuria results in a variable mix of acute and chronic hemolysis (nocturnal hemolysis is well recognized).
- Acute episodes may be precipitated by infection, transfusion, exercise, drugs, immunization, surgery, or iodinated intravenous contrast medium.
- Complications of paroxysmal nocturnal hemoglobinuria include:
 Imaging Findings of Paroxysmal nocturnal hemoglobinuria
- Renal cortical signal intensity loss (hemosiderin accumulates in the renal cortex when intravascular hemolysis results in the direct release of hemoglobin into the plasma).
- Venous thrombosis.
- Liver and spleen are usually of normal signal intensity in paroxysmal nocturnal hemoglobinuria, unless repeated transfusions have resulted in hepatic and splenic signal intensity loss owing to transfusional siderosis.
 Images of Paroxysmal nocturnal hemoglobinuria
Patient #1: MR images demonstrate paroxysmal nocturnal hemoglobinuria
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 References for Paroxysmal nocturnal hemoglobinuria
- Ross L. Titton, and Fergus V. Coakley. Case 51: Paroxysmal Nocturnal Hemoglobinuria with Thrombotic Budd-Chiari Syndrome and Renal Cortical Hemosiderin. Radiology 2002 225: 67-70.