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Pleomorphic adenoma

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Pleomorphic adenoma MRI 101.jpg

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[edit] Discussion of Pleomorphic adenoma

  • Salivary gland neoplasms are relatively rare. Most of them are benign (70%–80%) and found in the parotid glands (80%–90%).


  • Pleomorphic adenomas are the most common benign neoplasms of major salivary glands (followed by Warthin tumors )
  • Pleomorhpic adenomas clinically manifest as slowly growing painless masses.
  • Pleomorphic adenomas occur most often in the parotid gland (60%–90%) in people in the fourth and fifth decades of life.
  • Pleomorphic adenomas are usually solitary and unilateral.
  • Treatment is surgical as nontreated pleomorphic adenomas may undergo malignant transformation after decades.

[edit] Imaging Findings for Pleomorphic adenoma

  • At US, pleomorphic adenomas are hypoechoic, well-defined, lobulated tumors with posterior acoustic enhancement and may contain calcifications.
  • On CT, pleomorphic adenomas are typically smooth, well-marginated tumors. The attenuation values of the mass are usually homogeneous and higher than that of the surrounding gland. Tumor enhancement is variable and can result in a missed diagnosis if delayed images are not acquired (Pleomorphic adenomas are poorly enhancing in the early phase of contrast enhancement, though the amount of enhancement increases over time).
  • On MRI, pleomorphic adenomas are usually well-circumscribed, homogeneous masses with low intensity on T1-weighted images and high intensity on T2-weighted images. They commonly have a rim of decreased signal intensity on T2-weighted images. After gadolinium enhancement, the tumors are homogeneously enhancing unless they are large (unlike CT, MRI has no role in delayed imaging).

[edit] Images

Patient #1: MRI and PET images demonstrate a right parotid pleomorphic adenoma

[edit] See Also

[edit] External Links

[edit] References for Pleomorphic adenoma