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 Discussion of Pleomorphic adenoma
- Salivary gland neoplasms are relatively rare. Most of them are benign (70%–80%) and found in the parotid glands (80%–90%).
- Pleomorphic adenomas are the most common benign neoplasms of major salivary glands (followed by Warthin tumors )
- Pleomorhpic adenomas clinically manifest as slowly growing painless masses.
- Pleomorphic adenomas occur most often in the parotid gland (60%–90%) in people in the fourth and fifth decades of life.
- Pleomorphic adenomas are usually solitary and unilateral.
- Treatment is surgical as nontreated pleomorphic adenomas may undergo malignant transformation after decades.
 Imaging Findings for Pleomorphic adenoma
- At US, pleomorphic adenomas are hypoechoic, well-defined, lobulated tumors with posterior acoustic enhancement and may contain calcifications.
- On CT, pleomorphic adenomas are typically smooth, well-marginated tumors. The attenuation values of the mass are usually homogeneous and higher than that of the surrounding gland. Tumor enhancement is variable and can result in a missed diagnosis if delayed images are not acquired (Pleomorphic adenomas are poorly enhancing in the early phase of contrast enhancement, though the amount of enhancement increases over time).
- On MRI, pleomorphic adenomas are usually well-circumscribed, homogeneous masses with low intensity on T1-weighted images and high intensity on T2-weighted images. They commonly have a rim of decreased signal intensity on T2-weighted images. After gadolinium enhancement, the tumors are homogeneously enhancing unless they are large (unlike CT, MRI has no role in delayed imaging).
Patient #1: MRI and PET images demonstrate a right parotid pleomorphic adenoma
 See Also
 External Links
 References for Pleomorphic adenoma
- Ewa J. Bialek, Wieslaw Jakubowski, Piotr Zajkowski, Kazimierz T. Szopinski, and Antoni Osmolski. US of the Major Salivary Glands: Anatomy and Spatial Relationships, Pathologic Conditions, and Pitfalls. RadioGraphics 2006 26: 745-763.
- E-medicine pleomorphic adenoma article.