Pulmonary alveolar proteinosis

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[edit] Discussion of Pulmonary alveolar proteinosis

  • Pulmonary alveolar proteinosis (PAP) manifests as filling of the alveoli by a proteinaceous material that is positive at periodic acid–Schiff staining and rich in lipid, in association with an inflammatory response in the adjacent interstitium.
  • PAP is most common in adults between 20 and 50 years of age.
  • Dyspnea and nonproductive cough are the most common associated symptoms.
  • The diagnosis/treatment is with bronchoalveolar lavage.
  • Patients with PAP are susceptibility to pulmonary infections. Infectious agents include and opportunistic pathogens (especially nocardia) and common respiratory pathogens.

[edit] Imaging Findings for Pulmonary alveolar proteinosis

[edit] Plain film

  • Classic radiographic finding is bilateral, symmetric alveolar consolidation or ground-glass opacity, particularly in a perihilar or hilar distribution resembling pulmonary edema.

[edit] CT

  • CT typically shows diffuse ground-glass attenuation with superimposed crazy-paving pattern (intra- and interlobular septal thickening, often in polygonal shapes representing the secondary pulmonary lobule).

[edit] Images

Patient #1

Patient #1: Proven PAP but not quite the classic crazy-paving pattern

[edit] See Also

[edit] External Links

[edit] References for Pulmonary alveolar proteinosis