Discussion of Splenic angiosarcoma
- Primary angiosarcoma of the spleen is a very rare vascular neoplasm
- Represents the most common nonhematolymphoid malignant tumor of the spleen.
- It is found more frequently in older patients
- No gender predilection is apparent.
- Unlike angiosarcoma of the liver, splenic angiosarcoma has no documented association with exposure to carcinogens such as thorium dioxide, vinyl chloride, or arsenic.
- Typical symptoms at the time of presentation include abdominal pain, which may be accompanied by constitutional symptoms of fever, fatigue, and weight loss.
- Clinical complaints may be accompanied by hematologic disorders such as anemia, thrombocytopenia, or other coagulopathy.
- At physical examination, splenomegaly is almost always identified, and a focal left upper quadrant abdominal mass may be present as well.
- Patients with splenic angiosarcoma may also present with signs and symptoms of hemoperitoneum, since spontaneous rupture is a known complication in up to 30% of patients.
- Metastatic disease is common and typically involves the liver, lungs, bone, bone marrow, and lymphatic system.
- Prognosis is poor and almost all patients die within 1 year of diagnosis.
 Imaging Findings for Splenic angiosarcoma
- Imaging appearance of splenic angiosarcoma is that of an aggressive splenic mass, frequently with associated metastatic disease at the time of diagnosis. *Sonography, CT, and MR imaging all reveal evidence of marked splenomegaly.
- On sonograms, the most common appearance is that of a complex mass with heterogeneous echotexture.
- On CT scans, the most common appearance is that of an ill-defined splenic mass with heterogeneous contrast enhancement and areas of necrotic degeneration.
- MR imaging appearance of splenic angiosarcoma reflects the hemorrhagic nature of the tumor. Areas of increased and decreased signal intensity may be seen on images obtained with both T1- and T2-weighted pulse sequences, findings that are consistent with the presence of blood products and necrosis
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 References for Splenic angiosarcoma
- Robert M. Abbott, Angela D. Levy, Nadine S. Aguilera, Luis Gorospe, and William M. Thompson. From the Archives of the AFIP: Primary Vascular Neoplasms of the Spleen: Radiologic-Pathologic Correlation. RadioGraphics 2004 24: 1137-1163.