Discussion of Splenic hamartoma
- AKA splenomas, splenadenomas, or nodular hyperplasia of the spleen
- Rare benign lesions
- Autopsy series has shown that the incidence of splenic hamartoma ranges from 0.024% to 0.13%
- Hamartomas may occur at any age with equal gender predilection.
- Most patients have no symptoms, and the discovery of a splenic hamartoma is an incidental finding.
- Larger lesions may manifest with a palpable mass, splenomegaly, or rupture.
- Thrombocytopenia and anemia may occur from sequestration of hematopoietic cells.
- Hamartomas of the spleen have been associated with hamartomas elsewhere in the body and have been reported in cases of tuberous sclerosis.
- The importance of imaging splenic hamartomas lies in the need to differentiate them from malignant lesions of the spleen such as lymphoma and metastasis.
 Imaging Findings for Splenic hamartoma
- Sonography appears to be more sensitive than CT.
- On sonograms, splenic hamartomas are typically solid homogeneous masses. Most hamartomas are hyperechoic relative to the adjacent normal splenic parenchyma. On color Doppler images, these lesions often demonstrate increased blood flow.
- On angiograms, a splenic hamartoma appears as a hypervascular mass consisting of tumor vessels with aneurysmal dilatation, arteriovenous shunts, vascular lakes, and tumor blush resembling a typical malignant vascular pattern.
- On CT scans, hamartomas often appear nearly isoattenuating relative to normal spleen before and after intravenous administration of contrast material and, therefore, can be difficult to detect.
- On MRI, splenic hamartomas are isointense relative to normal splenic parenchyma on T1-weighted MR images, heterogeneously hyperintense on T2-weighted MR images, and heterogeneously diffusely enhanced on T1-weighted MR images obtained immediately after gadolinium injection. On delayed MR images, hamartomas were shown to have a more uniform homogeneous pattern of enhancement.
 See Also
 External Links
 References for Splenic hamartoma
- Robert M. Abbott, Angela D. Levy, Nadine S. Aguilera, Luis Gorospe, and William M. Thompson. From the Archives of the AFIP: Primary Vascular Neoplasms of the Spleen: Radiologic-Pathologic Correlation. RadioGraphics 2004 24: 1137-1163.