Discussion of Takayasu arteritis
- AKA pulseless disease
- Takayasu arteritis affects large and medium-sized arteries
- Characterized by ocular disturbances and marked weakening of the pulses in the upper extremities (hence the name pulseless disease).
- Also associated with fibrous thickening of the aortic arch with narrowing or virtual obliteration of the origins of the great vessels arising in the arch.
- Incidence in the United States was once estimated at 2.6 cases per 1,000,000 population per year.
- More often observed in patients of Asian origin, but it has been described in all racial groups.
- Females make up 80%–90% of patients with Takayasu arteritis, mostly in the second and third decades of life.
 Imaging Findings for Takayasu arteritis
- Gallium-67 radionuclide scanning may show increased uptake in the aorta and its branches when there is some degree of active inflammation.
- Duplex Doppler ultrasonography may be used to identify circumferential vessel wall thickening and thereby evaluate and monitor disease in the aorta and branch vessels
- CT scans may demonstrate mural thickening of the aorta, as well as luminal narrowing.
- Use of contrast material may reveal enhancing inflammatory lesions in the early stage of the disease, prior to the development of stenoses.
- Like CT, MRI can provide information on vessel wall thickening (even before lumen changes become apparent), luminal narrowing, and luminal dilatation *Enhancement of the thickened walls with gadolinium contrast material can be seen when some degree of activity is present. Th
- Angiography was the traditional method for diagnosing Takayasu arteritis.
- Characteristic arteriographic pattern that includes irregular vessel walls, stenosis, poststenotic dilatation, aneurysm formation, occlusion, and evidence of increased collateral circulation.
 External Links
 References for Takayasu arteritis
- Hyun K. Ha, Seung H. Lee, Sung E. Rha, Jee-H. Kim, Jae Y. Byun, Hyo K. Lim, Jin W. Chung, Jeong G. Kim, Pyo N. Kim, Moon-G. Lee, and Yong H. Auh. Radiologic Features of Vasculitis Involving the Gastrointestinal Tract. RadioGraphics 2000 20: 779-794.
- Marcio V. Nastri, Luciana P. S. Baptista, Ronaldo H. Baroni, Roberto Blasbalg, Luis F. de Ávila, Claudia C. Leite, Claudio C. de Castro, and Giovanni G. Cerri. Gadolinium-enhanced Three-dimensional MR Angiography of Takayasu Arteritis. RadioGraphics 2004 24: 773-786.