- Varicella-zoster virus pneumonia is the most serious complication of disseminated varicella-zoster virus infection with mortality rates of 9%–50%.
- Varicella-zoster virus most commonly causes self-limited benign disease (chickenpox) in children. However, in adults it tends to cause significant complications such as varicella-zoster virus pneumonia.
- More than 90% of cases of varicella-zoster virus pneumonia in adults occur in patients with lymphoma and immunocompromised patients.
- Histologic features of varicella-zoster virus pneumonia are those of diffuse alveolar damage. With recovery from the initial disease, spherical nodules are seen, scattered randomly throughout the lung parenchyma.
 Imaging Findings
 Plain film
- Multiple 5–10-mm ill-defined nodules that may be confluent and fleeting.
- Small, round nodules usually resolve within a week after the disappearance of the skin lesions but may persist for months.
- Lesions can calcify and can persist as numerous, well-defined, randomly scattered, 2–3-mm dense calcifications.
- Well-defined and ill-defined nodules diffusely throughout both lungs.
- Nodules with a surrounding halo of ground-glass opacity, patchy ground-glass opacity, and coalescence of nodules are also seen.
 See Also
 External Links
- Eun A Kim, Kyung Soo Lee, Steven L. Primack, Hye Kyung Yoon, Hong Sik Byun, Tae Sung Kim, Gee Young Suh, O Jung Kwon, and Joungho Han. Viral Pneumonias in Adults: Radiologic and Pathologic Findings. RadioGraphics 2002 22: 137S-149S.